“As you probably know, cetirizine (Zyrtec) and levocetirizine (Xyzal) are very popular OTC antihistamines. Where Does the FDA Stand on Zyrtec Withdrawal? Drilling down on the FDA reaction to our discovery about the Zyrtec itch:Ī few years ago we contacted one of the highest officials at the FDA. We contacted the FDA about this “discontinuation syndrome.” Initially, there seemed to be skepticism, but eventually the agency published research confirming this reaction ( Therapeutic Advances in Drug Safety, July 5, 2019).Īccording to Dutch researchers, gradual tapering of the cetirizine dose or a short course of corticosteroids might help alleviate the itching ( Drug Safety Case Reports, Dec. For some people, the itching lasted up to six weeks. Readers reported relentless itching within a few days of stopping this antihistamine. We first heard about cetirizine ( Zyrtec) withdrawal itching more than a decade ago. Then I did an online search that turned up Zyrtec withdrawal. At first, I thought it was due to a change in the weather. I stopped taking Zyrtec last week and have been suffering extreme itchiness since then. The FDA has finally acknowledged it exists, but there is no warning on the OTC label. Readers have been complaining about this reaction for many years. We now believe it is a Zyrtec withdrawal reaction. We have received a huge number of reports about post-cetirizine itch.
Other second-generation antihistamines include fexofenadine ( Allegra) and loratadine ( Claritin).
In other words, it doesn’t make you drowsy the way diphenhydramine ( Benadryl) does. It is considered a second-generation non-sedating antihistamine. Cetirizine ( Zyrtec) is an antihistamine often used to treat allergies, nasal congestion or hives.
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